[Temperature-sensitive mutants of the Venezuelan equine encephalomyelitis virus studied in the complementation test]

Investigation of 15 ts mutants of Venezuelan equine encephalomyelitis (VEE) virus by complementation tests permitted to divide these mutants into 5 complementation groups and to distinguish unclassifiable mutants. Mutants of 2 groups had RNA+/- or RNA- phenotype, i. e. had defects in RNA synthesis. Mutants in the other 3 groups had the RNA+ phenotype, and the temperature-sensitive defect of these mutants was in later stages of virus reproduction.