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Germ Cell Transplantation and Testis Tissue Xenografting in Mice
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Germ Cell Transplantation and Testis Tissue Xenografting in Mice

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[Germinal change and its significance in the hospital (author's transl)]

M Alexander

    Zentralblatt Fur Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, Betriebshygiene, Praventive Medizin
    |March 1, 1979
    PubMed

    Insights

    Over 20 years, hospital infections show a shift in bacteria. Gram-negative bacteria like Proteus and Pseudomonas increased, while Staphylococci and Streptococci decreased, indicating evolving antimicrobial resistance patterns.

    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Hospital Epidemiology

    Background:

    • Hospital-acquired infections (HAIs) pose a significant threat.
    • Understanding shifts in microbial pathogens is crucial for effective treatment.
    • Longitudinal data on bacterial spectrum changes in HAIs is limited.

    Purpose of the Study:

    • To investigate changes in the bacterial spectrum of hospital infections over the past 20 years.
    • To compare these changes across different hospital departments.
    • To identify trends in the prevalence of specific microorganisms.

    Main Methods:

    • Statistical comparative investigations of bacterial isolates.
    • Analysis of data from various hospital departments (Medical, Nephrology, Reanimation, Urology, Neurosurgery).
    • Evaluation of microbial changes over distinct time periods.

    Main Results:

    • Overall increase in Proteus, Pseudomonas, and Klebsiella (p=0.01%) and Candida; decrease in Staphylococci, Streptococci, Pneumococci, Clostridium, and Meningococci.
    • Nephrology: Increased Proteus, Pseudomonas, Klebsiella; decreased Enterococci, E. coli.
    • Reanimation: Increased Candida, Pseudomonas, Klebsiella, Enterobacter, Pneumococci; decreased Staphylococcus aureus, Enterococci, Streptococci.
    • Urology: Increased Pseudomonas, Enterobacter; decreased Staphylococcus aureus, Streptococci.
    • Neurosurgery: Gram-negative bacteria increased from 8.3% to 51.5%, notably E. coli, Enterobacter, and Pseudomonas.

    Conclusions:

    • Significant shifts in bacterial spectrum observed in hospital infections over two decades.
    • Increasing prevalence of Gram-negative bacteria (Proteus, Pseudomonas, Klebsiella, E. coli, Enterobacter) across multiple departments.
    • Decreasing trends in common Gram-positive bacteria (Staphylococci, Streptococci, Pneumococci) and some anaerobic bacteria.
    • These findings highlight the dynamic nature of HAIs and necessitate adaptation of infection control and treatment strategies.

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