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Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
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Updated: Jun 20, 2026

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
08:58

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Published on: March 11, 2017

Medium chain triglycerides and hepatic encephalopathy.

M H Morgan, C H Bolton, J S Morris

    Gut
    |March 1, 1974
    PubMed
    Summary
    This summary is machine-generated.

    Medium chain triglycerides (MCTs) did not cause clinical or electroencephalographic changes in cirrhosis patients. Arterial ammonia levels remained stable, suggesting MCTs are safe for patients with hepatic encephalopathy.

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    Area of Science:

    • Gastroenterology and Hepatology
    • Clinical Nutrition

    Background:

    • Cirrhosis of the liver can lead to malabsorption.
    • Hepatic encephalopathy is a serious complication of cirrhosis.
    • Medium chain triglycerides (MCTs) are proposed for malabsorption treatment.

    Purpose of the Study:

    • To evaluate the safety and clinical impact of oral medium chain triglycerides (C8 and C10) in patients with liver cirrhosis.
    • To assess the effects of MCTs on clinical status, electroencephalography (EEG), and arterial ammonia levels in cirrhosis patients, particularly those with hepatic encephalopathy.

    Main Methods:

    • Oral administration of short (C6) and medium chain triglycerides (C8, C10) to patients with cirrhosis.
    • Monitoring of clinical symptoms and electroencephalographic (EEG) activity.
    • Measurement of arterial ammonia levels before and after MCT administration.

    Main Results:

    • No significant clinical changes were observed following oral administration of short or medium chain triglycerides.
    • Electroencephalographic (EEG) recordings showed no alterations in patients with cirrhosis.
    • Arterial ammonia levels did not change significantly after the administration of medium chain triglycerides.

    Conclusions:

    • Oral medium chain triglycerides (MCTs) are not clinically contraindicated in patients with cirrhosis of the liver.
    • MCTs can be safely administered even to cirrhosis patients exhibiting signs of hepatic encephalopathy.
    • MCTs show potential as a therapeutic option for malabsorption in liver cirrhosis without adverse neurological effects.