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Related Experiment Videos

[Coagulation problems associated with massive blood transfusions. An experimental study (author's transl)].

G Witzke, W Abdulla

    Der Anaesthesist
    |July 1, 1979
    PubMed
    Summary

    Banked blood loses crucial clotting factors like factor VIII and factor V within days. This can cause dilution-coagulopathy during massive transfusions, requiring factor replacement therapy.

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    Haemophilia : the official journal of the World Federation of Hemophilia·2014

    Area of Science:

    • Hematology
    • Transfusion Medicine
    • Biochemistry

    Context:

    • Stored blood undergoes significant changes in cellular and plasma components.
    • Key coagulation factors, specifically antihaemophilic globulin (factor VIII) and pro-accelerin (factor V), rapidly degrade.
    • Reduced activity of these factors is evident within 3-5 days of storage.

    Purpose:

    • To investigate the degradation of essential coagulation factors in stored blood.
    • To understand the implications of factor VIII and factor V loss on transfusion safety.
    • To identify risks associated with using long-stored banked blood in massive transfusions.

    Summary:

    • Banked blood exhibits decreased function and concentration of vital components during storage.
    • Antihaemophilic globulin (factor VIII) and pro-accelerin (factor V) rapidly lose activity, with minimal levels remaining after 3-5 days.

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  • Massive transfusions, particularly with older banked blood, can lead to dilution-coagulopathy due to insufficient factor VIII and V supply, especially in patients with trauma or shock.

    • Impact:

    • Highlights the risk of dilution-coagulopathy in massive transfusion scenarios.
    • Underscores the importance of monitoring coagulation factor levels in stored blood.
    • Informs therapeutic strategies, emphasizing factor replacement under heparin for managing transfusion-related coagulopathy.