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Heparin bleeding due to qualitative platelet dysfunction.

D Heiden, R Rodvien, C H Mielke

    Angiology
    |September 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    Heparin, an anticoagulant, can cause bleeding by affecting platelet function. This study observed prolonged bleeding times in a patient receiving heparin for thromboembolic disease, suggesting a link to platelet dysfunction.

    Area of Science:

    • Hematology
    • Pharmacology

    Background:

    • Thromboembolic disease necessitates anticoagulant therapy, commonly with heparin.
    • Heparin is known to affect coagulation and platelet function.

    Observation:

    • A 26-year-old woman experienced arterial bleeding during heparin therapy for thromboembolic disease.
    • Bleeding recurred upon re-administration of heparin two years later.

    Findings:

    • Bleeding time was prolonged in the patient when she was ill and receiving heparin.
    • The patient's bleeding episodes correlated with heparin administration, suggesting a drug-induced effect.

    Implications:

    • Heparin may induce bleeding through qualitative platelet dysfunction.
    • Further investigation into heparin's effects on platelet function is warranted.

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  • This finding may inform clinical management of patients on heparin therapy.