Related Experiment Video
Updated: Jul 11, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
Renal amyloidosis and subcutaneous drug abuse
Abstract:
Two drug addicts who practiced subcutaneous injection of crushed tripelennamine and pentazocine tablets, a practice known as "skin-popping," developed nephrotic syndrome and demonstrated amyloidosis on renal biopsy. These patients had chronic inflammation of the skin in the form of abscesses and ulcerations. Although both patients were long-standing drug abusers, they had practiced intradermal drug administration for only 3 years. The occurrence of amyloidosis in these patients appears to relate to their particular drug habir and must be considered in the differential diagnosis of proteinuria in this patient population.
More Related Videos
Related Concept Videos
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Drug Distribution: Tissue Binding
For...
Drug Abuse and Addiction: Pharmacological Phenomena
Drug Toxicity: Risk factors
Drug Toxicity: Dose-Dependent Reactions

