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Neonatal aspergillosis accompanying fulminant necrotising enterocolitis
Archives of Disease in Childhood
|July 1, 1979
Abstract:
A preterm infant developed fulminant necrotising enterocolitis, subsequently resulting in death. Necropsy examination showed diffuse aspergillosis. Reports are reviewed, and possible mechanisms resulting in Aspergillus infection in this infant are discussed.
Insights
A preterm infant died from necrotising enterocolitis and invasive Aspergillus infection. This case highlights the potential for fungal infections in vulnerable neonates.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Pathology
Background:
- Necrotising enterocolitis (NEC) is a severe gastrointestinal emergency in preterm infants.
- Invasive fungal infections, particularly Aspergillus, are rare but devastating in neonates.
Observation:
- A preterm infant presented with fulminant necrotising enterocolitis.
- The infant unfortunately succumbed to the illness.
Findings:
- Post-mortem examination revealed diffuse aspergillosis, indicating a systemic Aspergillus infection.
- The necropsy findings suggest Aspergillus played a significant role in the infant's demise.
Implications:
- This case underscores the critical need for vigilance regarding invasive fungal infections in preterm neonates with NEC.
- Understanding potential mechanisms of Aspergillus acquisition and pathogenesis in this population is crucial for prevention and treatment strategies.