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Factor XIII levels in relation to gynaecological operations
Archives of Gynecology
|August 1, 1979
Summary
Factor XIII activity significantly decreases for about 40-50% after hysterectomy, regardless of surgical approach. This reduction begins within 2 hours and persists for 3 days post-operation.
Area of Science:
- Gynecology
- Hematology
- Surgical Research
Background:
- Hysterectomy is a common surgical procedure.
- Factor XIII plays a crucial role in hemostasis and wound healing.
- Postoperative changes in coagulation factors are clinically relevant.
Purpose of the Study:
- To investigate the impact of hysterectomy on Factor XIII activity.
- To compare Factor XIII activity following vaginal versus abdominal hysterectomy.
Main Methods:
- Factor XIII activity was measured using the antiseruminhibition test (Bohn and Haupt).
- Measurements were taken in the first 7 days post-operation.
- Patients underwent either vaginal (n=25) or abdominal (n=14) hysterectomy.
Main Results:
- A statistically significant reduction in Factor XIII activity (40-50%) was observed in both surgical groups.
- The reduction in activity commenced approximately 2 hours post-operation and lasted until the 3rd postoperative day.
- Neither the surgical approach (vaginal vs. abdominal), patient age, nor menstrual cycle phase significantly influenced the observed reduction.
Conclusions:
- Hysterectomy leads to a substantial and temporary decrease in Factor XIII activity.
- The surgical route does not appear to significantly alter this Factor XIII response.
- These findings highlight a transient hemostatic alteration following hysterectomy.