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Related Experiment Videos

Morphine hyperglycaemia.

W Feldberg, K P Gupta

    The Journal of Physiology
    |May 1, 1974
    PubMed
    Summary
    This summary is machine-generated.

    Morphine induces hyperglycemia in cats by acting on the ventral brain stem surface, likely in the upper medulla oblongata. This occurs after morphine enters the subarachnoid space via the foramina of Luschka from the cerebral ventricles.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Endocrinology

    Background:

    • Morphine is known to affect glucose metabolism.
    • The precise site of morphine's hyperglycemic action in the brain is not fully understood.

    Purpose of the Study:

    • To pinpoint the specific brain region responsible for morphine-induced hyperglycemia when administered into the cerebral ventricles.
    • To investigate the pathways involved in this hyperglycemic response.

    Main Methods:

    • Morphine sulfate was infused into various cerebrospinal fluid (CSF) compartments and brain regions in unanesthetized cats.
    • Blood glucose levels were monitored in the inferior vena cava.
    • Different dosages were used, including microinfusions into the posterior hypothalamus.

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    Main Results:

    • Microinfusions into the posterior hypothalamus did not cause hyperglycemia.
    • Infusion into the aqueduct entrance or fourth ventricle, and the subarachnoid space above the corpora quadrigemina or below the brain stem, induced hyperglycemia.
    • Larger doses were required for hyperglycemia when injected into the cisterna magna compared to cerebral ventricles.
    • Hypoglycemia was observed with infusions into the corpora quadrigemina.
    • Anesthesia reduced the hyperglycemic effect, but higher doses could overcome this.

    Conclusions:

    • Morphine-induced hyperglycemia from ventricular injection requires passage into the subarachnoid space through the foramina of Luschka.
    • The action site is likely on the ventral surface of the brain stem, specifically the upper medulla oblongata.
    • The corpora quadrigemina may be involved in a hypoglycemic response to morphine.