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Lead pica produced in rats.

C T Snowdon, B A Sanderson

    Science (New York, N.Y.)
    |January 11, 1974
    PubMed
    Summary
    This summary is machine-generated.

    Calcium-deficient rats readily consumed lead acetate solutions, even at high concentrations. This suggests calcium deficiency may contribute to the condition known as lead pica in young animals.

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    Area of Science:

    • Environmental toxicology
    • Nutritional science
    • Behavioral neuroscience

    Background:

    • Lead exposure is a significant public health concern, particularly in children.
    • Pica, the compulsive consumption of non-food items, is observed in lead poisoning.
    • The role of nutritional deficiencies in modulating lead intake is not fully understood.

    Purpose of the Study:

    • To investigate the effect of dietary calcium deficiency on voluntary lead acetate ingestion in weanling rats.
    • To determine if chronic lead exposure alters lead intake regulation.
    • To examine the relationship between lead exposure and calcium intake.

    Main Methods:

    • Weanling rats were assigned to low-calcium, iron-deficient, or control diets.
    • Voluntary intake of lead acetate solutions at varying concentrations was measured.

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  • Chronic lead acetate injections were administered to assess behavioral regulation.
  • Calcium ingestion was monitored in lead-injected females.

    • Main Results:

    • Rats on a low-calcium diet ingested significantly more lead acetate than iron-deficient or control rats.
    • Increased lead acetate ingestion persisted even at concentrations typically avoided by normal rats.
    • Chronic lead injections did not alter lead intake, suggesting a lack of regulatory behavior.
    • Lead-injected female rats showed increased calcium ingestion.

    Conclusions:

    • Dietary calcium deficiency enhances voluntary lead acetate ingestion in weanling rats.
    • Calcium deficiency may be a contributing factor to the development of lead pica.
    • Behavioral regulation of body lead levels appears to be impaired in young rats exposed to lead.