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Agranulocytosis associated with aprindine therapy
Archives of Internal Medicine
|October 1, 1979
Summary
Aprindine hydrochloride, an antiarrhythmic drug, is linked to agranulocytosis. This study reports the first case of agranulocytosis with elevated aprindine serum levels, suggesting a potential mechanism for bone marrow suppression.
Area of Science:
- Pharmacology
- Toxicology
- Hematology
Background:
- Aprindine hydrochloride is an investigational antiarrhythmic agent.
- It is primarily used for preventing ventricular dysrhythmias.
- Known toxic effects include neurological symptoms, gastrointestinal distress, and agranulocytosis.