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Related Experiment Videos

Systemic cellular hypersensitivity induced by an intestinally absorbed antigen.

J L Perrotto, L M Hang, K J Isselbacher

    The Journal of Experimental Medicine
    |July 1, 1974
    PubMed
    Summary
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    Intestinal administration of Schistosoma mansoni eggs or antigens can induce systemic cellular immune sensitization in mice. This sensitization enhances granulomatous inflammation, demonstrating a link between gut exposure and systemic immune responses.

    Area of Science:

    • Immunology
    • Parasitology
    • Gastroenterology

    Background:

    • Schistosoma mansoni eggs are potent inducers of immune responses.
    • The route of antigen administration can significantly influence immune sensitization.

    Purpose of the Study:

    • To investigate whether intestinal administration of Schistosoma mansoni antigens can induce systemic cellular immune sensitization.
    • To characterize the nature of the immune response elicited by intestinal antigen exposure.

    Main Methods:

    • Neonatal and adult mice were administered intact Schistosoma mansoni eggs or soluble egg antigens via intragastric or intraduodenal routes.
    • Systemic cellular hypersensitivity was assessed by observing the granulomatous inflammatory response to intravenously injected S. mansoni eggs in the lungs.

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    Main Results:

    • Intragastric administration of S. mansoni eggs or antigens to neonatal mice induced systemic cellular hypersensitivity.
    • Adult mice required specific conditions (e.g., bicarbonate with intragastric administration, or intraduodenal administration) for partial or full sensitization.
    • Sensitized mice exhibited accelerated and augmented pulmonary granulomatous inflammation.

    Conclusions:

    • Intestinal administration of Schistosoma mansoni antigens can effectively induce systemic cellular immune sensitization.
    • The route and conditions of antigen administration are critical for achieving immune sensitization via the intestine.
    • This study highlights the potential of the gastrointestinal tract as a route for inducing systemic immunity.