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Concentration effect studies with oral metoclopramide.

D N Bateman, C Kahn, D S Davies

    British Journal of Clinical Pharmacology
    |August 1, 1979
    PubMed
    Summary
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    Metoclopramide did not significantly speed gastric emptying in healthy males. Sedation was noted at higher doses, and a specific side effect, akathisia, occurred at high plasma concentrations, suggesting dose and route matter.

    Area of Science:

    • Pharmacology
    • Gastroenterology

    Background:

    • Metoclopramide is a commonly prescribed medication.
    • Its effects on gastric emptying and central nervous system side effects require further investigation.

    Purpose of the Study:

    • To evaluate the effects of single oral doses of metoclopramide on gastric emptying and central nervous system side effects.
    • To compare oral metoclopramide's effects with placebo in healthy male volunteers.

    Main Methods:

    • Six healthy male volunteers received single oral doses of 10 mg and 20 mg metoclopramide or placebo.
    • Gastric emptying was assessed by measuring ethanol absorption.
    • Central nervous system side effects, including sedation and akathisia, were monitored.

    Main Results:

    Related Experiment Videos

    • Metoclopramide did not significantly alter the rate of gastric emptying as measured by ethanol absorption.
    • Sedation was observed 1 hour after the 20 mg oral dose (P < 0.05).
    • Akathisia occurred in subjects with peak plasma concentrations above 100 ng/ml.

    Conclusions:

    • The route of administration is crucial for metoclopramide's action.
    • A clear concentration-effect relationship for metoclopramide's effect on the stomach could not be established.
    • Further research is needed to understand the pharmacokinetics and pharmacodynamics of metoclopramide.