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Phototherapy and neonatal liver function.

K L Tan, E Jacob, K S Chua

    Biology of the Neonate
    |January 1, 1979
    PubMed
    Summary
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    Phototherapy effectively reduces bilirubin levels in infants. This treatment, even for 72 hours, does not negatively impact infant liver function, as shown by normal liver enzyme tests.

    Area of Science:

    • Neonatal Medicine
    • Pediatric Gastroenterology
    • Phototherapy Research

    Background:

    • Hyperbilirubinemia is common in full-term infants.
    • Phototherapy is a standard treatment for neonatal jaundice.
    • Concerns exist regarding potential phototherapy effects on infant liver function.

    Purpose of the Study:

    • To evaluate the impact of phototherapy on liver function in infants with hyperbilirubinemia.
    • To assess changes in specific liver enzymes and function tests after phototherapy exposure.

    Main Methods:

    • Two groups of healthy, full-term infants with hyperbilirubinemia received phototherapy for 72 hours.
    • Liver function tests (SGPT, SICD, SAP, HSAP, total protein, albumin) were measured.
    • Bromsulphalein (BSP) tests were conducted before and after phototherapy.

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  • Control groups of infants without hyperbilirubinemia were used for comparison.

    • Main Results:

    • Phototherapy significantly decreased bilirubin levels in treated infants.
    • No significant changes were observed in SGPT, SICD, SAP, HSAP, total protein, or albumin levels.
    • Bromsulphalein (BSP) test results remained unaltered after 72 hours of phototherapy.
    • Liver function test results were comparable between phototherapy and control groups.

    Conclusions:

    • Phototherapy for 72 hours is safe for infant liver function.
    • The treatment effectively manages hyperbilirubinemia without adverse hepatic effects.
    • Phototherapy does not appear to impair key indicators of liver function in neonates.