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Anaphylactoid reaction to mannitol
Abstract:
A 16-year old boy with a lesion of the right eye developed, during the preoperative administration of a mannitol infusion, an anaphylactoid reaction characterized by hypotension, periorbital oedema and bronchospasm. This quickly resolved following cessation of the infusion and appropriate therapeutic measures. There were no long-lasting effects. We considered mannitol the causative agent because of its temporal relationship to the reaction and our inability to seriously implicate any other medication. A history of childhood atopy may have been a predisposing factor.
Insights
A teenage boy experienced an anaphylactoid reaction, including hypotension and bronchospasm, during a mannitol infusion for eye surgery. The reaction resolved after stopping the mannitol, suggesting it was the likely cause.
Area of Science:
- Anesthesiology
- Ophthalmology
- Allergy and Immunology
Background:
- Mannitol is commonly used as an osmotic diuretic in preoperative settings.
- Anaphylactoid reactions are rare but serious adverse events.
- Identifying causative agents in adverse drug reactions is crucial for patient safety.