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[Xanthogranulomatous pyelonephritis in the infant. A report on 4 cases (author's transl)]
Insights
Xanthogranulomatous pyelonephritis (XGP) in children presents in diffuse or localized forms, often affecting young boys and girls respectively. Proteus infection is frequently observed in pediatric XGP cases.
Area of Science:
- Pediatric Nephrology
- Pediatric Urology
- Pediatric Pathology
Background:
- Xanthogranulomatous pyelonephritis (XGP) is a rare, chronic granulomatous inflammatory disease affecting the kidney.
- This review focuses on pediatric cases, analyzing a total of 43 cases from literature and new observations.
Observation:
- Four new cases of pediatric XGP are presented: three diffuse and one localized.
- A review of 39 previously published pediatric cases (1963-1978) was conducted.
- The diffuse form was more common in boys, while the localized form was more prevalent in girls.
Findings:
- Of the 43 cases, 34 were diffuse and 9 were localized.
- XGP predominantly affected children under five years old (29 cases).
- Proteus infection was identified in 23 cases, suggesting a potential etiological link.
Implications:
- The etiology of XGP remains unclear, necessitating further research into its pathogenesis.
- Understanding the clinical presentation and epidemiological data aids in diagnosing and managing pediatric XGP.
- The study highlights the importance of considering XGP in children presenting with specific urinary tract infections and renal inflammation.
Abstract:
Four cases of xanthogranulomatous pyelonephritis in children are reported. In three cases, the disease took a diffuse form and in the fourth it was of a localised form. Around these cases, the authors review 39 case histories published between 1963 and 1978 and which involve only children. An over-all assessment of the 43 cases thus gathered together allows the general picture of xanthogranulomatous pyelonepn 9 cases, it was of the localised type; and in 4 cases, the pyelonephritis only involved one or another pyelon in patients with re-duplication. The diffuse type is more common in boys and the localised type in girls. Twenty-nine cases were found in children of less than five years. In 23 cases, there was a proteus infection. The etio-pathogenesis of xanthogranulomatous pyelonephritis remains obscure. The main clinical and therapeutic problems are dealt with.