Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating immune complexes in various thyroid diseases.

D Brohee, G Delespesse, M J Debisschop

    Clinical and Experimental Immunology
    |June 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Phase variation in the modulation of the human immune response.

    Immunology today·2014
    Same author

    Are anti-vitamin K drugs contraindicated with cetuximab during head-and-neck cancer concomitant radiotherapy?

    Acta clinica Belgica·2013
    Same author

    Epidemiology and clinical characteristics of larynx and hypopharynx carcinoma: a comparative study in the Hainaut and review of the literature.

    Acta chirurgica Belgica·2013
    Same author

    Basophils are recruited to inflamed lungs and exacerbate memory Th2 responses in mice and humans.

    Allergy·2012
    Same author

    [Comment on: Thyroid nodules, benign or malignant].

    Revue medicale de Bruxelles·2012
    Same author

    Hematopoietic progenitor cells are innate Th2 cytokine-producing cells.

    Allergy·2011
    Same journal

    The many faces of cytokine storm syndrome: immunopathogenic mechanisms and clinical implications for a better patient management.

    Clinical and experimental immunology·2026
    Same journal

    PD-1 Engagement and Circulating Th17 Effector Activity During Secukinumab Treatment in Plaque Psoriasis.

    Clinical and experimental immunology·2026
    Same journal

    Henoch-Schoenlein purpura (HSP) like lesions in IL12RB1 and IL12B defects - A multi-centric experience from India.

    Clinical and experimental immunology·2026
    Same journal

    Case Series on the Efficacy of Daratumumab in Treating Patients with Anti-Interferon-Gamma Autoantibodies.

    Clinical and experimental immunology·2026
    Same journal

    Deleterious germline CARD11 gain-of-function variants alter human B-cell and CD4+ T-cell differentiation and function.

    Clinical and experimental immunology·2026
    Same journal

    Clinical, genetic, and functional characterization of novel NFKB1 variants in Chinese patients with primary immunodeficiency.

    Clinical and experimental immunology·2026
    See all related articles

    Circulating immune complexes (CIC) were found in 26% of thyroid disease patients, significantly higher than controls. These immune complexes correlate with thyroid autoimmune disorders and microsomal antibodies.

    Area of Science:

    • Immunology
    • Endocrinology
    • Thyroidology

    Background:

    • Circulating immune complexes (CIC) are implicated in various autoimmune conditions.
    • Their role in thyroid diseases requires further elucidation.

    Purpose of the Study:

    • To investigate the prevalence and significance of CIC in patients with diverse thyroid diseases.
    • To explore correlations between CIC and specific thyroid conditions, autoantibodies, and clinical parameters.

    Main Methods:

    • A C1q solid phase radioassay was employed to detect CIC in 171 patients with thyroid diseases and control subjects.
    • Data analysis focused on correlating CIC presence with disease type, autoantibody levels, thyroid function tests, and patient demographics.

    Main Results:

    Related Experiment Videos

    • CIC were detected in 26% of thyroid disease patients versus 8% of controls.
    • Prevalence was higher (33-55%) in autoimmune thyroid disorders (Hashimoto's goitre, thyroiditis, myxoedema, Graves' disease) and diffuse goitre.
    • CIC correlated with the presence of anti-microsomal thyroid antibodies, but not their titre, age, sex, exophthalmos, thyroid function, or anti-thyroglobulin antibodies.

    Conclusions:

    • Circulating immune complexes are more prevalent in patients with thyroid diseases, particularly autoimmune forms.
    • CIC presence is associated with anti-microsomal antibodies, suggesting a role in thyroid autoimmunity.
    • No association was found between CIC and thyroid function or clinical manifestations like exophthalmos.