Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transfer factor therapy in hyperimmunoglobulinaemia E syndrome.

H H Kesarwala, R V Prasad, R Szep

    Clinical and Experimental Immunology
    |June 1, 1979
    PubMed
    Summary

    Transfer factor (TF) therapy showed significant clinical improvement in children with severe atopic dermatitis and immune deficiencies. This immune modulation offers a promising treatment avenue for hyperimmunoglobulinaemia E syndrome.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Patient specific in vitro follicle development in response to ovarian freezing and culture.

    Reproduction & fertility·2026
    Same author

    Three-dimensional visualisation of human ovarian follicles using a whole-mount immunolabelling and optical tissue clearing method.

    Reproduction & fertility·2025
    Same author

    Influence of routine follow-up radiographs on recommendations for management of antebrachial fractures in dogs.

    Australian veterinary journal·2025
    Same author

    Anthropometric and Physiological Measures in Individuals With At-Risk Mental State (ARMS) Compared With Individuals With Schizophrenia: Findings From a Lower Middle-Income Country.

    Early intervention in psychiatry·2025
    Same author

    Four-dimensional ultrasound guided embryo transfers improve live birth rates when compared to the clinical touch technique: a randomised controlled trial.

    Scientific reports·2023
    Same author

    Demographic and clinical correlates of suicidal ideation in individuals with at-risk mental state (ARMS): A study from Pakistan.

    Early intervention in psychiatry·2023

    Area of Science:

    • Immunology
    • Dermatology
    • Pediatrics

    Background:

    • Investigated the therapeutic potential of transfer factor (TF) in two children with severe, intractable atopic dermatitis.
    • Patients presented with recurrent pyogenic skin infections, hyperimmunoglobulinaemia E (hyper-IgE), defective neutrophil chemotaxis, and depressed cell-mediated immunity.

    Observation:

    • Both children experienced striking clinical improvement, including resolution of skin infections, pruritus, and eczema.
    • One patient remained lesion-free for 13 months post-therapy, while the second experienced a recurrence after 8 months.
    • Patients were successfully weaned off steroids and antibiotics.

    Findings:

    • Transfer factor (TF) administration did not alter T cell rosette numbers or lymphocyte blastic transformation.

    Related Experiment Videos

  • TF therapy led to conversion of skin-test reactivity in both patients.
  • Correction of polymorphonuclear chemotaxis was observed in one patient.
  • A marked, persistent rise in serum IgE was noted in both patients without clinical side effects.

    • Implications:

    • Transfer factor (TF) therapy may benefit patients with hyperimmunoglobulinaemia E (hyper-IgE) syndrome.
    • Findings support the hypothesis that T lymphocyte deficiency contributes to eczema in hyper-IgE syndrome.
    • TF therapy represents a potential treatment for complex immune-related dermatological conditions.