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Related Experiment Videos

Effects of nefopam on visual tracking.

J P Belleville, F Dorey, J W BEllville

    Clinical Pharmacology and Therapeutics
    |October 1, 1979
    PubMed
    Summary

    D-amphetamine improved coordination and alertness in sleep-deprived individuals, while pentazocine impaired performance and caused negative side effects. Nefopam and placebo showed no significant effects on coordination or subjective feelings.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Human Performance

    Background:

    • Sleep deprivation impairs cognitive and motor functions.
    • Understanding drug effects on performance is crucial for safety and efficacy.
    • Investigating psychostimulants and analgesics in altered physiological states.

    Purpose of the Study:

    • To evaluate the impact of nefopam, d-amphetamine, and pentazocine on hand-eye coordination.
    • To assess subjective effects of these drugs in sleep-deprived healthy males.
    • To compare drug-induced changes in performance against placebo.

    Main Methods:

    • A critical tracking task assessed hand-eye coordination.
    • Healthy male volunteers participated after sleep deprivation.
    • Two doses of nefopam, d-amphetamine, and pentazocine were administered, along with a placebo.

    Main Results:

    • D-amphetamine (10 mg orally) enhanced tracking performance and subjective alertness, but increased anxiety.
    • Pentazocine (45 mg intramuscularly) significantly impaired tracking performance and induced negative subjective effects like depression and nausea.
    • Nefopam (2 doses) and placebo did not produce significant changes in coordination or subjective experience.

    Conclusions:

    • D-amphetamine demonstrates performance-enhancing and mood-altering effects in sleep-deprived individuals.
    • Pentazocine impairs psychomotor function and elicits undesirable side effects.
    • Nefopam does not appear to significantly affect hand-eye coordination or subjective states under these conditions.

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