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Related Experiment Videos

Auditory evoked responses in multiple sclerosis.

K Robinson, P Rudge

    Lancet (London, England)
    |May 24, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Auditory evoked responses (AERs) were abnormal in most multiple sclerosis patients, even without hearing loss. These early brainstem auditory pathway responses reveal subclinical neurological deficits.

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    Area of Science:

    • Neuroscience
    • Clinical Neurology
    • Audiology

    Background:

    • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
    • Auditory pathway involvement in MS can lead to subclinical deficits.
    • Early components of auditory evoked responses (AERs) reflect brainstem auditory pathway function.

    Purpose of the Study:

    • To investigate the utility of early auditory evoked responses (waves I-V) in detecting brainstem auditory pathway abnormalities in patients with multiple sclerosis.
    • To correlate AER findings with clinical neurological signs, specifically internuclear ophthalmoplegia and brainstem abnormalities.

    Main Methods:

    • Studied 30 patients diagnosed with multiple sclerosis.
    • Recorded and analyzed early auditory evoked responses (waves I-V).

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  • Correlated AER results with the presence of internuclear ophthalmoplegia and other detectable brainstem abnormalities.

    • Main Results:

    • Abnormalities in early auditory evoked responses were observed in 22 out of 30 patients (73%).
    • All patients exhibiting internuclear ophthalmoplegia had abnormal AERs.
    • Half of the patients with no clinically detectable brainstem abnormalities still showed abnormal AERs.
    • No patients included in the study reported clinical deafness.

    Conclusions:

    • Early auditory evoked responses (AERs) are highly sensitive in detecting subclinical brainstem auditory pathway dysfunction in multiple sclerosis.
    • AER testing can identify neurological deficits not apparent through clinical examination or audiometry.
    • AERs serve as a valuable tool for assessing the extent of central nervous system involvement in MS.