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The hypercoagulability states.

C F Arkin, A S Hartman

    CRC Critical Reviews in Clinical Laboratory Sciences
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Hypercoagulability states, or hyperactivity of the hemostatic system, significantly impact clinical outcomes. This review details conditions promoting venous and arterial thrombosis and their laboratory evaluation.

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    Area of Science:

    • Hematology
    • Clinical Medicine
    • Pathophysiology

    Background:

    • While hemorrhagic disorders are well-studied, hypercoagulability states pose a greater clinical challenge.
    • Hypercoagulable states are poorly defined by laboratory diagnostics.
    • These states contribute to significant thrombotic complications.

    Purpose of the Study:

    • To review disorders associated with hypercoagulable states.
    • To discuss the pathophysiologic basis of hypercoagulability.
    • To emphasize laboratory evaluation methods for these conditions.

    Main Methods:

    • Review of existing literature on hypercoagulability.
    • Categorization of disorders based on thrombosis type (venous vs. arterial).
    • Discussion of pathophysiologic mechanisms.

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    Main Results:

    • Hypercoagulable states are classified into two groups: those promoting venous thrombosis and those promoting arterial thrombosis.
    • Venous thrombosis is linked to coagulation activation, while arterial thrombosis involves platelet plug formation.
    • The pathophysiologic basis and laboratory evaluation of these distinct groups are discussed.

    Conclusions:

    • Hypercoagulability, leading to thrombotic complications, has a greater clinical impact than hemorrhagic disorders.
    • Understanding the distinct mechanisms of venous and arterial thrombosis in hypercoagulable states is crucial.
    • Standardized laboratory evaluation is essential for diagnosing and managing hypercoagulable states.