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Updated: Aug 4, 2026
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Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
Published on: May 30, 2013
Optimal antibiotic therapy in cholera
Bulletin of the World Health Organization
|January 1, 1968
Summary
Optimal oral tetracycline dosing effectively manages cholera, reducing diarrhea duration and vibrio presence. This study establishes predictable efficacy for tetracycline regimens, outperforming chloramphenicol and sulfaguanidine in cholera treatment.
Area of Science:
- Infectious Diseases
- Gastroenterology
- Pharmacology
Background:
- Intravenous fluid and electrolyte replacement is standard for cholera hydration.
- Oral tetracycline shows promise in reducing cholera duration and bacterial load.
- Optimal tetracycline dosage and comparative efficacy against other adjuncts remain unclear.
Purpose of the Study:
- To establish an optimal dose schedule for oral tetracycline in cholera management.
- To compare the efficacy of tetracycline with chloramphenicol and sulfaguanidine.
- To assess the impact of tetracycline on diarrhea volume, duration, and Vibrio eradication.
Main Methods:
- Investigated three different oral tetracycline dose schedules.
- Administered 3 g or 4 g of tetracycline to cholera patients.
- Compared treatment outcomes with chloramphenicol and sulfaguanidine adjuncts.
Main Results:
- Tetracycline regimens at 3 g or 4 g demonstrated predictable efficacy.
- Tetracycline significantly reduced diarrhea volume and duration.
- Chloramphenicol showed some benefit, while sulfaguanidine offered minimal advantage over tetracycline.
Conclusions:
- Established effective oral tetracycline dose schedules for cholera treatment.
- Oral tetracycline is a superior adjunct compared to chloramphenicol and sulfaguanidine.
- Tetracycline effectively eradicates Vibrio cholerae, reducing relapse rates.
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