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The localization of [3H]-desipramine in central nerve terminals studied with electron microscope autoradiography and
Experientia
|September 15, 1979
Abstract:
The cellular and subcellular distribution of [3H]-desipramine (DMI) in rat brain was studied by electron microscope (EM) autoradiography and by subcellular fractionation. A considerable proportion of label was found to be bound to the membranes of presynaptic nerve terminals, as well as to sites inside those terminals.