Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comments on mutagenesis risk estimation.

W L Russell

    Genetics
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Oversimplified hypotheses about mutagenesis can mislead genetic risk estimation. Direct determination of transmitted mutations in mammals, like the specific-locus method in mice, remains crucial for accurate assessment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Radiation-induced genetic damage in mice.

    Progress in nuclear energy. Series 6 Biological sciences·2014
    Same author

    Ovarian transplantation as a tool in genetic research.

    Genetics·2010
    Same author

    A histological study of eye abnormalities in the C57 black strain of mice.

    The Anatomical record·2010
    Same author

    Effects of ENU dosage on mouse strains.

    Mammalian genome : official journal of the International Mammalian Genome Society·2000
    Same author

    Differential response of mouse male germ-cell stages to radiation-induced specific-locus and dominant mutations.

    Genetics·1998
    Same author

    The role of ultrasonography and inferior vena cava filter placement in high-risk trauma patients.

    The American surgeon·1997
    Same journal

    Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

    Genetics·2026
    Same journal

    Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

    Genetics·2026
    Same journal

    Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

    Genetics·2026
    Same journal

    Identification of two Cryptococcus neoformans heme transporters involved in Fhb1-mediated nitrosative stress protection in a fission yeast model.

    Genetics·2026
    Same journal

    Analysis of a hypomorphic mei-P26 mutation reveals coordination between developmental programming of germ cells and meiotic chromosome dynamics.

    Genetics·2026
    Same journal

    Neural and Genetic Mechanisms Regulating Copulation Latency in Male Drosophila melanogaster.

    Genetics·2026
    See all related articles

    Area of Science:

    • Genetics
    • Toxicology
    • Radiation Biology

    Background:

    • Several hypotheses oversimplify mutagenesis and genetic risk estimation.
    • These include DNA content-based models for radiation and chemical mutagenesis.
    • The concept of universal mutational effects across organisms and the REC unit are also questioned.

    Purpose of the Study:

    • To highlight the limitations of current hypotheses in mutagenesis.
    • To emphasize the necessity of direct experimental determination of mutation frequencies.
    • To advocate for the utility of specific methods in mammals for risk assessment.

    Main Methods:

    • Critically evaluating existing hypotheses on mutagenesis.
    • Reviewing the limitations of extrapolating data between species and radiation types.

    Related Experiment Videos

  • Highlighting the specific-locus method in mice as a viable tool.

    • Main Results:

    • Hypotheses linking mutation frequency solely to DNA content are oversimplified.
    • Qualitative similarity of mutational effects across organisms is not universally applicable.
    • Directly measured mutation frequencies in mammals are essential for accurate risk assessment.

    Conclusions:

    • Oversimplified models for mutagenesis can be misleading for genetic risk estimation.
    • Direct determination of transmitted mutation frequencies in mammals is critical.
    • The specific-locus method in mice is a cost-effective approach for chemical testing requirements.