Related Experiment Video
Updated: Jul 31, 2026

Plunge Freezing: A Tool for the Ultrastructural and Immunolocalization Studies of Suspension Cells in Transmission Electron Microscopy
Published on: May 5, 2017
Myospherulosis: further ultrastructural observations.
Myospherulosis, a condition observed in patient buttocks, may represent altered red blood cells. Ultrastructural findings suggest spherules contain dense bodies and filaments, potentially hemoglobin polymers.
Area of Science:
- Pathology
- Cell Biology
- Dermatology
Background:
- Myospherulosis is a poorly understood condition.
- Previous hypotheses regarding its origin are limited.
Purpose of the Study:
- To investigate the ultrastructural characteristics of myospherulosis.
- To determine the cellular origin of myospherulosis.
Main Methods:
- Ultrastructural examination of patient tissue samples.
- Incubation of red blood cells with tetracycline ointment for comparison.
Main Results:
- Observed spherules with double electron-dense walls, dense bodies, and filaments.
- Red blood cells incubated with tetracycline showed similar electron-dense deposits.
Conclusions:
- Findings support the hypothesis that myospherulosis involves altered red blood cells.
- Filaments may be hemoglobin polymers, and parent bodies may originate from histiocytes.
More Related Videos
08:07Single Myofiber Isolation and Culture from a Murine Model of Emery-Dreifuss Muscular Dystrophy in Early Post-Natal Development
Published on: July 1, 2020
08:41Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions
Published on: August 14, 2021
Related Concept Videos
Studying the Cytoskeleton
Microscopic Anatomy of Skeletal Muscles
The muscle sarcolemma is a plasma membrane enclosing each muscle cell that conducts electrical signals called action potentials. The sarcolemma extends into the cell to form T-tubules, ensuring the neural impulses are uniformly distributed across the entire muscle...