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Related Experiment Videos

The pulse wave arrival time (QKd interval) in normal children.

B B Bercu, R Haupt, R Johnsonbaugh

    The Journal of Pediatrics
    |November 1, 1979
    PubMed
    Summary

    The QKd interval, measuring pulse wave arrival time, was standardized for children using height correction. This allows for clinical studies in children and reveals progressive arterial stiffening with age.

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    Area of Science:

    • Pediatric Cardiology
    • Biomedical Engineering
    • Vascular Physiology

    Background:

    • The QKd interval measures pulse wave arrival time, valuable for assessing cardiovascular health in adults.
    • Standardization of QKd measurements in children is crucial for pediatric clinical studies.

    Purpose of the Study:

    • To standardize the QKd interval measurement in a pediatric population.
    • To establish normal ranges for QKd in children aged 7 months to 18 years.
    • To investigate the relationship between pulse wave velocity (PWV) and age in children.

    Main Methods:

    • Measurements of the QKd interval were obtained from 63 healthy children.
    • A regression equation was developed to correct QKd for height (QKd = 56.6 + 0.797H).
    • Pulse wave velocity (PWV) was calculated and correlated with age.

    Main Results:

    • A height-corrected QKd equation was established: QKd = 56.6 + 0.797H (H in cm).
    • Pulse rate correction was found unnecessary for resting subjects.
    • PWV increases with age (PWV = 2.44 + 0.203 A) with r = 0.823, indicating decreasing arterial elasticity.

    Conclusions:

    • The derived QKd equation enables standardized clinical assessments in children.
    • The findings suggest a progressive loss of arterial functional elasticity throughout childhood.
    • This research provides a basis for utilizing QKd interval in pediatric cardiovascular research.

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