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[Method for determination of the bleomycin inactivating enzyme acitivity in tissues]
Zeitschrift Fur Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology
|January 1, 1975
Abstract:
An enzyme that inactivates Bleomycin (BLM) can be extracted from tissue. The activity of this enzyme varies markedly in different tissues. In the present paper, a method is described by which the activity of the BLM-inactivating enzyme in different organs and tissues of mice can be determined. The highest activity is found in liver; lower enzyme concentrations occur in the testis, spleen, lung and brain. In skin this enzyme is almost completely missing.