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Related Experiment Video

Updated: Jul 9, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

Urinary concentrating ability in early experimental pyelonephritis.

D Kaye, H Rocha

The Journal of Clinical Investigation

|July 1, 1970

Summary

Early experimental pyelonephritis in rats impairs urinary concentrating ability, but this defect is reversible and not linked to permanent kidney damage. Recovery of concentrating function correlates with reduced bacterial load.

Area of Science:

Nephrology
Infectious Diseases
Experimental Medicine

Background:

Pyelonephritis, a kidney infection, can potentially impair renal function.
Understanding the impact of early-stage pyelonephritis on urinary concentrating ability is crucial for assessing reversibility and prognosis.

Purpose of the Study:

To investigate the effect of experimental bilateral pyelonephritis on the urinary concentrating ability of rats.
To determine if the observed concentrating defect is reversible and its correlation with bacterial load and renal histology.

Main Methods:

Rats were infected with Enterococcus, Staphylococcus aureus, or Escherichia coli to induce pyelonephritis.
Urinary concentrating ability was assessed by measuring maximum urinary osmolality.
Effects of antimicrobial therapy on bacterial titers, osmolality, and recovery were evaluated.

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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis

Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis

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Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

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Last Updated: Jul 9, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis

Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis

Published on: July 18, 2017

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

Main Results:

Experimental pyelonephritis significantly reduced maximum urinary osmolality in rats.
The concentrating defect was reversible, with osmolality returning to normal levels as bacterial infections cleared.
Rapid decrease in bacterial titers correlated with improved urinary concentrating ability, independent of histological findings.

Conclusions:

Early experimental pyelonephritis causes a transient defect in urinary concentrating ability.
The concentrating defect is rapidly reversible and not indicative of permanent renal damage.
Recovery of renal concentrating function is directly linked to the resolution of bacterial infection.