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Updated: Oct 5, 2026

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies
14:10

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Published on: January 31, 2013

Morphologic changes in extraocular muscles of the dystrophic hamster

D H Percy, J H Thakar, K P Strickland

    Muscle & Nerve
    |July 1, 1979
    PubMed

    Insights

    Cardiomyopathic hamsters exhibit muscle abnormalities in both cardiac and skeletal tissues, alongside ocular issues. These findings suggest the hamster may serve as a valuable model for studying human ocular myopathies.

    Area of Science:

    • Ophthalmology
    • Muscle Biology
    • Animal Models

    Background:

    • Cardiomyopathic hamsters (UM-X7.1 strain) present with myopathy affecting skeletal and cardiac muscles.
    • These hamsters also display various ocular abnormalities.

    Purpose of the Study:

    • To investigate the histopathological changes in the extraocular muscles of cardiomyopathic hamsters.
    • To assess the potential of this animal model for studying ocular myopathies.

    Main Methods:

    • Light and electron microscopy were employed to examine extraocular muscle tissues.
    • Histopathological analysis focused on identifying degenerative and regenerative changes within muscle fibers.

    Main Results:

    • Observed changes included coagulation necrosis, myofibril lysis, mitochondrial alterations, and phagocytic cell infiltration.
    • Evidence of regeneration, such as duplicated myoblast nuclei and myofibrillogenesis, was also noted.

    Conclusions:

    • The observed lesions in extraocular muscles are likely of myogenic origin.
    • The cardiomyopathic hamster serves as a relevant animal model for investigating human ocular myopathies.

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