Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolutionary nucleotide replacements in DNA.

T H Jukes, J L King

    Nature
    |October 18, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Silent codon changes are more common than amino acid altering changes during molecular evolution. Comparisons of viral genes reveal all nine possible types of nucleotide sequence changes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Art therapy masks reflect emotional changes in military personnel with PTSS.

    Scientific reports·2024
    Same author

    Association of whole mtDNA, an NADPH G11914A variant, and haplogroups with high physical performance in an elite military troop.

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2021
    Same author

    "The devil's in the detail": Release of an expanded, enhanced and dynamically revised forensic STR Sequence Guide.

    Forensic science international. Genetics·2018
    Same author

    D5S2500 is an ambiguously characterized STR: Identification and description of forensic microsatellites in the genomics age.

    Forensic science international. Genetics·2016
    Same author

    Contrast adaptation is spatial frequency specific in mouse primary visual cortex.

    Neuroscience·2015
    Same author

    Poor health among smokers obtaining colonoscopy screening: making the case for cessation intervention.

    Public health·2015

    Area of Science:

    • Molecular Biology
    • Evolutionary Biology
    • Bioinformatics

    Background:

    • Advancements in analytical techniques provide extensive data on messenger RNA (mRNA) sequences.
    • Comparative analysis of homologous nucleotide sequences across different organisms offers insights into evolutionary processes.

    Purpose of the Study:

    • To analyze and compare nucleotide sequences of homologous genes from different organisms.
    • To investigate the frequency and types of nucleotide changes in molecular evolution.

    Main Methods:

    • Comparative analysis of mRNA nucleotide sequences.
    • Examination of codon changes, including silent (degenerate) and code-altering mutations.
    • Analysis of gene sequences from viruses phi X174 and G4 to identify all nine types of codon changes.

    Related Experiment Videos

    Main Results:

    • Silent codon changes occur more frequently than amino acid altering changes.
    • Nucleotide sequence comparisons reveal multiple types of differences beyond amino acid residue changes.
    • All nine theoretical types of codon changes were observed in the comparison of viral genes.

    Conclusions:

    • Nucleotide sequence comparisons provide a more detailed view of evolutionary changes than amino acid comparisons.
    • The study highlights the significance of various nucleotide changes in the context of molecular evolution.