The development of crystallographic enzymology

Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199).

Blood cancer journal·2015

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

Cell death & disease·2015

Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo.

British journal of pharmacology·2012

Genetically defining the mechanism of Puma- and Bim-induced apoptosis.

Cell death and differentiation·2011

Ceramide-induced G2 arrest in rhabdomyosarcoma (RMS) cells requires p21Cip1/Waf1 induction and is prevented by MDM2 overexpression.

Cell death and differentiation·2007

A caspase-8-independent component in TRAIL/Apo-2L-induced cell death in human rhabdomyosarcoma cells.

Cell death and differentiation·2003

Trafficking of phosphatidylinositol by phosphatidylinositol transfer proteins.

Biochemical Society symposium·2007

Regulation of phospholipase D activity, membrane targeting and intracellular trafficking by phosphoinositides.

Biochemical Society symposium·2007

Evolution of the diverse biological roles of inositols.

Biochemical Society symposium·2007

Understanding the biological significance of diphosphoinositol polyphosphates ('inositol pyrophosphates').

Biochemical Society symposium·2007

Multiple functions of inositolphosphorylceramides in the formation and intracellular transport of glycosylphosphatidylinositol-anchored proteins in yeast.

Biochemical Society symposium·2007

Inositol polyphosphate kinases: regulators of nuclear function.

Biochemical Society symposium·2007

Facet engineering of iron metal-organic framework for enhanced photoreduction of carbon dioxide to ethylene.

Chemical communications (Cambridge, England)·2026

Degradation Structure of EPDM Revealed by Sequential PCA and Kendrick Mass Three-Dimensional Analysis of Temperature-Dependent High-Resolution Mass Spectra.

Analytical chemistry·2026

Ambient-Processed Organic Solar Cells Achieving Nearly 20.5% Efficiency and Industrially Viable Environmental Stability.

Advanced materials (Deerfield Beach, Fla.)·2026

Dual-interface engineering: synergy of self-floating triphase interface and heterointerface for boosted photocatalytic H2O2 production.

Chemical communications (Cambridge, England)·2026

Highly selective photocatalytic oxidation of benzylic C-H bonds in alkylbenzenes to ketones.

Dalton transactions (Cambridge, England : 2003)·2026

Cortical neuron calcium response to infrared neural stimulation depends on the spatiotemporal thermal gradient.

Biomedical optics express·2026

Related Experiment Videos

The development of crystallographic enzymology

Related Concept Videos

Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199).

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo.

Genetically defining the mechanism of Puma- and Bim-induced apoptosis.

Ceramide-induced G2 arrest in rhabdomyosarcoma (RMS) cells requires p21Cip1/Waf1 induction and is prevented by MDM2 overexpression.

A caspase-8-independent component in TRAIL/Apo-2L-induced cell death in human rhabdomyosarcoma cells.

Trafficking of phosphatidylinositol by phosphatidylinositol transfer proteins.

Regulation of phospholipase D activity, membrane targeting and intracellular trafficking by phosphoinositides.

Evolution of the diverse biological roles of inositols.

Understanding the biological significance of diphosphoinositol polyphosphates ('inositol pyrophosphates').

Multiple functions of inositolphosphorylceramides in the formation and intracellular transport of glycosylphosphatidylinositol-anchored proteins in yeast.

Inositol polyphosphate kinases: regulators of nuclear function.

Facet engineering of iron metal-organic framework for enhanced photoreduction of carbon dioxide to ethylene.

Degradation Structure of EPDM Revealed by Sequential PCA and Kendrick Mass Three-Dimensional Analysis of Temperature-Dependent High-Resolution Mass Spectra.

Ambient-Processed Organic Solar Cells Achieving Nearly 20.5% Efficiency and Industrially Viable Environmental Stability.

Dual-interface engineering: synergy of self-floating triphase interface and heterointerface for boosted photocatalytic H2O2 production.

Highly selective photocatalytic oxidation of benzylic C-H bonds in alkylbenzenes to ketones.

Cortical neuron calcium response to infrared neural stimulation depends on the spatiotemporal thermal gradient.

Related Experiment Videos

The development of crystallographic enzymology

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