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Related Experiment Videos

Controlled trial of amitriptyline in general practice.

T G Blashki, R Mowbray, B Davies

    British Medical Journal
    |January 16, 1971
    PubMed
    Summary

    Amitriptyline, at 150 mg/day, was the most effective treatment for depression and anxiety in women. All treatments showed improvement, with similar side effect distribution.

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    Area of Science:

    • Psychiatry and Clinical Psychology

    Background:

    • Depressive illness is a common condition affecting women attending general practice.
    • Pharmacological interventions are frequently used to manage symptoms of depression and anxiety.

    Purpose of the Study:

    • To compare the efficacy of amitriptyline (75 mg and 150 mg/day), amylobarbitone (150 mg/day), and an inert placebo in treating depressive illness in women.

    Main Methods:

    • A controlled, double-blind trial was conducted over four weeks.
    • Four matched groups of women with depressive illness participated.
    • Improvements were assessed using depression and anxiety measures at 7 and 28 days.

    Main Results:

    • All treatment groups showed improvement in depression and anxiety symptoms at 7 and 28 days.
    • Amitriptyline 150 mg/day demonstrated the most consistent relief from depression and anxiety.
    • Adverse side effects were distributed evenly across all four treatment groups.

    Conclusions:

    • Amitriptyline, particularly at a 150 mg/day dosage, is an effective treatment for depression and anxiety in women.
    • The study highlights the efficacy of amitriptyline compared to amylobarbitone and placebo.
    • Further research may explore long-term effects and optimal dosing strategies.

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