Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone marrow transplantation.

C C Congdon

    Science (New York, N.Y.)
    |March 19, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Bone marrow transplantation uses stem cells to treat blood disorders. While effective for immune deficiencies, the graft-versus-host reaction remains a key challenge for wider application.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lymphatic tissue changes in rats flown on Spacelab Life Sciences-2.

    Journal of applied physiology (Bethesda, Md. : 1985)·1996
    Same author

    Effects of spaceflight on the number of rat peripheral blood leukocytes and lymphocyte subsets.

    Journal of leukocyte biology·1994
    Same author

    The first official meeting of the International Society for Experimental Hematology.

    Experimental hematology·1993
    Same author

    Polysorbate toxicity in neonatal rats and mice.

    Pharmacology & toxicology·1991
    Same author

    A review of certain low-level ionizing radiation studies in mice and guinea pigs.

    Health physics·1987
    Same author

    Hematological measurements in rats flown on Spacelab shuttle, SL-3.

    The American journal of physiology·1987
    Same journal

    Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

    Science (New York, N.Y.)·2026
    Same journal

    Local signals, systemic decline.

    Science (New York, N.Y.)·2026
    Same journal

    The mechanics of liver regeneration.

    Science (New York, N.Y.)·2026
    Same journal

    Computing in a memory with physics.

    Science (New York, N.Y.)·2026
    Same journal

    Retraction.

    Science (New York, N.Y.)·2026
    Same journal

    Making time.

    Science (New York, N.Y.)·2026
    See all related articles

    Area of Science:

    • Hematology
    • Immunology
    • Transplantation Medicine

    Background:

    • Bone marrow transplantation (BMT) is crucial for treating hematological diseases.
    • Current BMT techniques rely on stem cell circulation and normal physiological processes.
    • Experimental systems involve bone marrow destruction to demonstrate transplant efficacy.

    Purpose of the Study:

    • To explore the therapeutic applications of bone marrow transplantation.
    • To highlight the role of stem cell grafts in treating genetic blood disorders.
    • To discuss the historical development and future prospects of BMT.

    Main Methods:

    • Needle-and-syringe techniques for marrow procurement and grafting.
    • Utilizing induced bone marrow destruction (irradiation, chemicals) for experimental models.

    Related Experiment Videos

  • Clinical studies, including those with identical twins, to assess graft efficacy.

    • Main Results:

    • Successful treatment of rare hereditary immune-deficiency disorders in children.
    • Demonstration of BMT's value in genetic diseases affecting marrow function.
    • Identification of the graft-versus-host reaction as a significant challenge.

    Conclusions:

    • Bone marrow transplantation offers therapeutic potential for various diseases.
    • Overcoming the graft-versus-host reaction is critical for broader clinical use.
    • Advancements in cell separation, banking, and tissue culture are key for future BMT success.