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[Whipple's disease].

F H Franken, U Boenigk, H Schmitt

    Deutsche Medizinische Wochenschrift (1946)
    |June 20, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Whipple's disease, a rare condition causing intestinal issues, can be effectively treated with antibiotics like tetracycline. Early diagnosis through intestinal biopsy and prompt treatment lead to significant remission and symptom reversal.

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    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Pathology

    Context:

    • Whipple's disease is a rare, often fatal gastrointestinal disorder.
    • Characterized by PAS-positive macrophages, villous atrophy, and pseudocysts in the small intestine.
    • Historically diagnosed late, often post-mortem, with limited treatment options.

    Purpose:

    • To report two unique cases of Whipple's disease in female patients.
    • To highlight the efficacy of tetracycline treatment in severe cases.
    • To document the partial regression of intestinal mucosal changes post-treatment.

    Summary:

    • Two female patients with Whipple's disease presented with severe symptoms.
    • Both patients achieved rapid and complete recovery after a few weeks of tetracycline treatment.

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  • Follow-up examinations confirmed sustained remission and partial reversal of intestinal pathology.

    • Impact:

    • Demonstrates tetracycline's effectiveness in treating Whipple's disease, even in severe presentations.
    • Suggests antibiotics are a viable treatment, supporting a bacterial etiology.
    • Highlights the importance of intestinal biopsy for early diagnosis and improved patient outcomes.