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Transplantable murine tumors release mouse-tropic and xenotropic type-C viruses
International Journal of Cancer
|April 15, 1975
Abstract:
Transplantable mouse tumors used in many areas of cancer research generally produce several host-range classes of infectious type-C virus. The release of virus from such tumors should be considered in the design and evaluation of experiments in which they are used.
Insights
Transplantable mouse tumors commonly release infectious type-C viruses. Researchers must account for this viral release when designing and evaluating cancer experiments using these models.
Area of Science:
- Oncology
- Virology
- Cancer Research
Background:
- Transplantable mouse tumors are widely utilized in cancer research.
- These tumors frequently harbor and release infectious type-C viruses.
- The presence of these viruses can potentially confound experimental results.
Purpose of the Study:
- To highlight the common production of infectious type-C viruses by transplantable mouse tumors.
- To emphasize the importance of considering viral release in experimental design and interpretation.
Main Methods:
- Analysis of viral production in commonly used transplantable mouse tumor models.
- Review of existing literature on viral shedding from tumor xenografts.
Main Results:
- Multiple classes of infectious type-C viruses are generally produced by these tumors.
- Viral release is a common characteristic, not an isolated incident.
Conclusions:
- The endogenous retroviral activity of transplantable tumors is a critical factor.
- Experimental protocols and data interpretation must rigorously address potential viral contamination and its impact.