Pepsin secretion, gastric motility and mucosal blood flow in the anaesthetized cat

1. There is a weak relationship between pepsin output and gastric mucosal blood flow (MBF) during vagal stimulation. When compared with the strong relationship between H(+) output and MBF, this suggests little dependence of pepsin secretion on MBF.2. Gastric MBF per unit H(+) output was significantly greater during vagal stimulation, when H(+) secretion was accompanied by pepsin secretion, than during pentapeptide stimulation when no pepsin was secreted.3. Pepsin output was not reduced during splanchnic stimulation whereas MBF and acid output were, when blood pressure was kept constant.4. Splanchnic stimulation did not produce any pepsin secretion.5. Gastric motor responses to vagal stimulation and to I.A. injections of acetylcholine were equally reduced by splanchnic stimulation.