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Related Experiment Videos

Persistent phenothiazine dyskinesia treated with tetrabenazine.

R B Godwin-Austen, T Clark

    British Medical Journal
    |October 2, 1971
    PubMed
    Summary

    Tetrabenazine effectively treated persistent phenothiazine dyskinesia in some patients. This study found abnormal movements were abolished in three out of six participants, suggesting tetrabenazine

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Clinical Medicine

    Background:

    • Persistent dyskinesia is a significant side effect of phenothiazine medication.
    • Current treatment options for phenothiazine-induced dyskinesia are limited.

    Purpose of the Study:

    • To evaluate the efficacy of tetrabenazine in treating persistent phenothiazine dyskinesia.

    Main Methods:

    • A double-blind, controlled trial involving six patients with persistent phenothiazine dyskinesia.
    • Patients were treated with tetrabenazine 100 mg daily in divided doses.
    • Diazepam served as the control medication.

    Main Results:

    • Three out of six patients experienced complete abolition of abnormal movements.
    • Two patients showed some improvement, comparable to diazepam treatment.
    • No significant adverse events were reported.

    Conclusions:

    • Tetrabenazine demonstrates potential as a treatment for persistent phenothiazine dyskinesia.
    • Further research is warranted to confirm efficacy and optimal dosing.
    • Tetrabenazine offers a promising therapeutic option for managing this movement disorder.

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