Inactivated Proplex for the haemophiliac with inhibitors. A case report

Inactivated prothrombin complex (Proplex) with a Kingdon time between 100 and 138 seconds effected functional recovery and adequate haemostasis in a haemophiliac with inhibitors of the high-responder type at comparatively low cost, and with no adverse effects. Home treatment was successful. Liver function remained normal during treatment. Statistically significant changes occurred in the prothrombin time (PT), fibrinogen levels and the thrombin time after each infusion. No evidence of diffuse intravascular coagulation (DIC) was ever detected. The inhibitor level decreased from 10 to 2 Bethesda units, and the radio-immunoassay (RIA) for Australia antigen remained negative.