[Nosologic isolation of involutional depressions and features of their dynamics during psychopharmacotherapy]

Clinical follow-up studies of 92 patients registered in a psychiatric dispensary with involutional depression confirmed the diagnosis only in 51 cases. Some clinical features in the hereditary loading, premorbid personality traits and premanifest symptoms in patients with a confirmed diagnosis during follow-up examinations were demonstrated. Variants in the development of the clinical picture, related to signs of therapeutic pathomorphosis and due to long-term psychopharmacotherapy were eliminated. An underestimation of this circumstance may lead to an unjustified narrowing of the limits of involutional depression.