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Related Experiment Videos

Eperythrozoon coccoides. I. Effect on the interferon response in mice.

L A Glasgow, T Odugbemi, P Dwyer

    Infection and Immunity
    |October 1, 1971
    PubMed
    Summary

    Eperythrozoon coccoides, a rodent blood parasite, causes chronic infections and anemia. Infected mice show suppressed interferon production, potentially increasing susceptibility to viral infections.

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    Area of Science:

    • * Immunology
    • * Infectious Diseases
    • * Rodent Pathology

    Background:

    • * Eperythrozoon coccoides is a common blood parasite in rodents, causing chronic infections in mouse colonies.
    • * Infection leads to initial parasitemia and anemia, followed by a latent phase.

    Purpose of the Study:

    • * To investigate the impact of Eperythrozoon coccoides infection on interferon production in mice.
    • * To explore the relationship between reticuloendothelial system involvement and interferon response impairment.

    Main Methods:

    • * Mice were infected with Eperythrozoon coccoides.
    • * Interferon production was assessed following induction with Newcastle disease virus, Chikungunya virus, and poly I:C during the acute infection phase.

    Main Results:

    • * Mice infected with Eperythrozoon coccoides exhibited significant suppression of interferon production.
    • * This suppression occurred in response to viral and synthetic interferon inducers.

    Conclusions:

    • * Reticuloendothelial system involvement during Eperythrozoon coccoides infection is linked to impaired interferon response.
    • * Suppressed interferon production may contribute to increased susceptibility to viral infections in affected animals.

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