The analgesic action of some flavonoids in the hot plate test

Albino-Swiss male mice were tested in the hot plate test. Oligomeric procyjanidin (OL-1), rutin, quercetin, hyperoside and vitexin rhamnoside were administered intraperitoneally in doses 3.5 and 10 mg/kg. It was found that OL-1, rutin and hyperoside but not vitexin rhamnoside exert analgesic action, whereas quercetin even decreases the pain threshold level. The mechanism of the analgesic action of flavonoids remains to be explained.