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Updated: Mar 20, 2026
05:14
A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
5.5K
Risk factors for doxorubicin-induced congestive heart failure
Annals of Internal Medicine
|November 1, 1979
Summary
Doxorubicin dose and patient age increase congestive heart failure risk. A weekly schedule significantly lowers this risk compared to a 3-week schedule, aiding clinical decisions.
Area of Science:
- Cardiology
- Oncology
- Pharmacology
Background:
- Doxorubicin is a widely used chemotherapy agent.
- Congestive heart failure is a known, serious side effect of doxorubicin therapy.
- Identifying risk factors is crucial for patient management.
Purpose of the Study:
- To identify potential risk factors for doxorubicin-induced congestive heart failure.
- To analyze the relationship between doxorubicin dosage, administration schedule, and heart failure incidence.
- To inform clinical practice regarding doxorubicin use.
Main Methods:
- Retrospective analysis of 4018 patient records.
- Examination of overall incidence of drug-induced congestive heart failure.
- Correlation analysis of risk factors including total dose, schedule, age, performance status, sex, race, and tumor type.
Main Results:
- Overall incidence of doxorubicin-induced congestive heart failure was 2.2%.
- Increased risk was associated with higher cumulative doxorubicin doses and advancing patient age.
- A weekly doxorubicin schedule showed a significantly lower incidence of heart failure compared to the every 3-week schedule.
Conclusions:
- Doxorubicin dose and patient age are significant risk factors for congestive heart failure.
- Weekly administration of doxorubicin may reduce cardiotoxicity.
- Findings support better risk-benefit assessment and development of safer anthracycline analogues.
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