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[Postnatal phagocytic maturation (author's transl)].

H Gómez-Estrada, G Gómez Guitrón, M E Ramos-Damian

    Archivos De Investigacion Medica
    |January 1, 1979
    PubMed
    Summary
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    Phagocytic index (PI) in children increases significantly after the first neonatal month. This immune function marker, crucial for fighting infections, develops substantially from infancy through preschool years.

    Area of Science:

    • Immunology
    • Pediatrics
    • Cellular Biology

    Context:

    • The immune system undergoes significant development during early childhood.
    • Polymorphonuclear leukocytes play a critical role in innate immunity.
    • Understanding phagocytic function is essential for assessing immune competence in neonates and infants.

    Purpose:

    • To investigate the phagocytic index (PI) in clinically healthy children across different age groups, including premature infants, newborns, infants, and preschool children.
    • To establish reference ranges for PI in pediatric populations.
    • To determine the relationship between age, body weight, and phagocytic activity.

    Summary:

    • Seventy-two children (12 premature, 31 newborns, 25 infants, 4 preschool) were studied.

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  • The phagocytic index (PI) of polymorphonuclear leukocytes was measured using latex particles in autologous serum.
  • PI levels ranged from 5.55-11.05 in prematures, 11.09-15.00 in newborns/infants, and 15.08-21.97 in preschool children, compared to 19.21-22.70 in adults.
  • A marked increase in PI was observed after the first neonatal month or upon reaching a body weight over 4.250 Kg.

    • Impact:

    • Provides normative data for phagocytic index in pediatric age groups.
    • Highlights the developmental trajectory of phagocytic function in early life.
    • Suggests a critical window for immune system maturation around the first neonatal month and specific body weight milestones.