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Rapid sulfonamide disc sensitivity test for meningococci
Applied Microbiology
|July 1, 1968
Summary
This study correlated sulfadiazine minimal inhibitory concentrations (MIC) with sulfathiazole disc inhibition zones for Neisseria meningitidis. A significant linear relationship was found, enabling the classification of bacterial strains into sensitive and resistant groups.
Area of Science:
- Microbiology
- Antimicrobial Susceptibility Testing
Background:
- Neisseria meningitidis is a significant human pathogen.
- Accurate susceptibility testing is crucial for effective treatment.
Purpose of the Study:
- To correlate minimal inhibitory concentrations (MIC) of sulfadiazine with sulfathiazole disc inhibition zones for Neisseria meningitidis.
- To establish quantitative criteria for interpreting disc diffusion test results.
Main Methods:
- Determined MIC of sulfadiazine for 90 Neisseria meningitidis strains using a plate dilution technique.
- Correlated geometric mean MIC values with inhibition zone diameters from sulfathiazole disc tests.
- Analyzed the linear relationship between logarithm of MIC values and zone diameters.
Main Results:
- A highly significant linear relationship was observed between logarithm of geometric mean MIC values and zone diameters.
- Both MIC determination and disc diffusion tests effectively separated strains into sensitive and resistant populations.
- Quantitative criteria for disc test interpretation were successfully established.
Conclusions:
- Sulfathiazole disc diffusion test is a reliable method for determining sulfadiazine susceptibility in Neisseria meningitidis.
- Established criteria facilitate accurate interpretation of disc diffusion tests for clinical and epidemiological purposes.