Related Experiment Videos
Sulfadiazine-resistant group A Neisseria meningitidis
Science (New York, N.Y.)
|September 6, 1968
Abstract:
A meningitis epidemic due to Group A meningococci was unusual in that most of the strains isolated from patients were generally resistant to sulfadiazine. This is the first report of sulfonamide resistance in an epidemic strain of Neisseria meningitidis Group A.
Insights
A Group A meningococcal meningitis epidemic showed unusual resistance to sulfadiazine in most strains. This marks the first documented sulfonamide resistance in an epidemic Neisseria meningitidis Group A strain.
Area of Science:
- Microbiology
- Epidemiology
- Infectious Diseases
Background:
- Meningitis epidemics are often caused by Neisseria meningitidis.
- Sulfadiazine has historically been an effective treatment for bacterial meningitis.
Purpose of the Study:
- To report on the antimicrobial resistance patterns observed during a Group A meningococcal meningitis epidemic.
- To document the first instance of sulfonamide resistance in an epidemic strain of Neisseria meningitidis Group A.
Main Methods:
- Isolation and identification of Neisseria meningitidis Group A strains from patients during an epidemic.
- Antimicrobial susceptibility testing of isolated strains, focusing on sulfadiazine resistance.
Main Results:
- Most Neisseria meningitidis Group A strains isolated during the epidemic exhibited resistance to sulfadiazine.
- This resistance pattern was unusual compared to historical data for this pathogen.
Conclusions:
- The findings indicate a significant emergence of sulfadiazine resistance in epidemic Group A meningococci.
- This necessitates a re-evaluation of treatment strategies for Neisseria meningitidis Group A infections.