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Related Experiment Videos

Cimetidine: effect on pancreatic and biliary function in man.

D P Maudgal, D Lawrence, F M Sanderson

    British Journal of Clinical Pharmacology
    |September 1, 1979
    PubMed
    Summary

    Cimetidine did not alter pancreatic and biliary function in patients with peptic ulcers. However, it increased bacterial deconjugation of bile acids in the gastrointestinal tract, as shown by a bile acid breath test.

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    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Digestive System Physiology

    Background:

    • Cimetidine is a common treatment for peptic ulcer disease.
    • Its effects on pancreatic and biliary function require further investigation.
    • Understanding drug-induced changes in the gastrointestinal microbiome is crucial.

    Purpose of the Study:

    • To evaluate the impact of oral cimetidine on pancreatic and biliary function.
    • To assess changes in postprandial jejunal tryptic activity and bile acid metabolism.
    • To investigate the effect of cimetidine on bacterial deconjugation of bile acids.

    Main Methods:

    • Eight patients with active peptic ulcer disease received cimetidine (1.6 g/day) for 6 weeks.
    • Pancreatic and biliary function tests were performed, including postprandial jejunal aspirates and gallbladder emptying.

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  • A [14C]-glycocholate bile acid breath test was used to assess bacterial deconjugation.

    • Main Results:

    • Postprandial jejunal tryptic activity and bile acid concentration remained unchanged.
    • Postprandial gallbladder emptying was not affected by cimetidine treatment.
    • The bile acid breath test revealed a significant increase in 14CO2, indicating enhanced bacterial deconjugation of bile acids.

    Conclusions:

    • Cimetidine does not significantly impair pancreatic or biliary function in patients with peptic ulcers.
    • Cimetidine treatment leads to increased bacterial deconjugation of bile acids in the gastrointestinal tract.
    • These findings highlight a potential interaction between cimetidine and the gut microbiome.