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Analog-digital molecular cell computer.

E A Liberman

    Bio Systems
    |August 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    The cell functions as a molecular stochastic computer (MCC) using DNA, RNA, and proteins to process information and predict future states. This molecular computing system can even reorganize its own programming, mirroring universal computer capabilities.

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    Area of Science:

    • Biophysics
    • Molecular Biology
    • Computational Biology

    Background:

    • The living cell operates via a complex molecular machinery.
    • Understanding cellular information processing is key to biophysics.

    Purpose of the Study:

    • To propose the cell as a molecular stochastic computer (MCC).
    • To explore the computational capabilities of biological molecules.

    Main Methods:

    • Analysis of molecular interactions and information flow within the cell.
    • Comparison of cellular processes to universal computer functions.
    • Investigating the role of DNA, RNA, and proteins as molecule-words and operators.
    • Considering Brownian motion and molecular complementarity in computation.
    • Exploring cyclic nucleotides and proton channels as analog computer components.

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    Main Results:

    • The cell's molecular machinery can be conceptualized as a parallel-successive molecular stochastic computer (MCC).
    • MCC utilizes DNA, RNA, and proteins as 'molecule-words' and molecular devices as 'operators'.
    • The system predicts future states and synthesizes necessary molecules, akin to a universal computer.
    • Self-reorganization of the cellular program is possible.
    • Cyclic nucleotides and proton channels act as analog computer elements for solving equations.

    Conclusions:

    • The cell's computational abilities are based on molecular stochastic processes.
    • MCC offers a framework for understanding cellular information processing and prediction.
    • Biophysics must consider the computational aspect of biological systems, not just physical laws.