Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Horizontal canal input to cat extraocular motoneurons.

Y Uchino, S Suzuki, T Miyazawa

    Brain Research
    |November 16, 1979
    PubMed
    Summary

    Stimulating the horizontal canal nerve (HCN) in cats causes specific synaptic responses in eye muscles. This research clarifies neuronal pathways controlling eye movements and vestibular reflexes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [The mechanism of glucose intolerance in patients with Graves' disease].

    Nihon Naibunpi Gakkai zasshi·1992
    Same author

    Role of colony-stimulating factor-1 in macrophage activation in tumor-bearing mice.

    Journal of immunology (Baltimore, Md. : 1950)·1992
    Same author

    Oxygen and reduced umbilical blood flow trigger the first breath of human neonates.

    Acta paediatrica Japonica : Overseas edition·1992
    Same author

    [Instantaneous changes in sleep stage due to the sound of a passing truck].

    Nihon eiseigaku zasshi. Japanese journal of hygiene·1992
    Same author

    [Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver].

    Nihon Geka Gakkai zasshi·1992
    Same author

    Validity of electrode placement at Fpz to detect alpha wave.

    The Japanese journal of psychiatry and neurology·1992

    Area of Science:

    • Neuroscience
    • Vestibular System
    • Oculomotor Control

    Background:

    • The horizontal canal nerve (HCN) plays a crucial role in vestibular reflexes and eye movement control.
    • Understanding the precise neural pathways activated by the HCN is essential for comprehending oculomotor function.

    Purpose of the Study:

    • To investigate the synaptic connections and neuronal responses in extraocular motoneurons following horizontal canal nerve stimulation.
    • To elucidate the specific pathways involved in the vestibulo-ocular reflex (VOR) originating from the horizontal semicircular canals.

    Main Methods:

    • Extracellular recordings of synaptic potentials in identified extraocular motoneurons of anesthetized cats.
    • Electrical stimulation of the horizontal canal nerve (HCN).
    • Analysis of evoked excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs) in different motoneuron pools.

    Main Results:

    • Weak HCN stimulation evoked disynaptic EPSPs in ipsilateral medial rectus (i-MR) and contralateral lateral rectus (c-LR) motoneurons.
    • Disynaptic IPSPs were observed in ipsilateral lateral rectus (i-LR) motoneurons.
    • Longer latency IPSPs, likely trisynaptic, were recorded in contralateral medial rectus (c-MR) motoneurons.
    • No significant influence of HCN stimulation was found on superior rectus (SR), inferior rectus (IR), superior oblique (SO), and inferior oblique (IO) motoneurons.

    Conclusions:

    • The horizontal canal nerve (HCN) has a specific projection pattern to extraocular motoneurons, primarily affecting medial and lateral rectus muscles.
    • A polysynaptic inhibitory pathway from the HCN to contralateral medial rectus motoneurons via vestibular and IIIrd nucleus interneurons is proposed.
    • These findings contribute to a detailed map of the neural circuitry underlying the horizontal vestibulo-ocular reflex.

    Related Experiment Videos