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Ketamine kinetics: decerebrate vs. intact cats.

J E Heavner, D C Bloedow

    Canadian Journal of Physiology and Pharmacology
    |August 1, 1979
    PubMed
    Summary

    Decerebrate cats show altered ketamine pharmacokinetics, with lower drug distribution and half-life compared to intact cats. This highlights the need to consider animal preparation when interpreting drug concentrations.

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    Area of Science:

    • Veterinary Pharmacology
    • Neuroscience
    • Drug Metabolism

    Background:

    • Understanding drug pharmacokinetics is crucial for accurate dosing and therapeutic outcomes in animal studies.
    • Decerebration, a surgical preparation, significantly alters physiological conditions and may impact drug disposition.

    Purpose of the Study:

    • To compare the pharmacokinetic parameters of ketamine in decerebrate versus intact cats.
    • To investigate the influence of decerebration on ketamine distribution and elimination.

    Main Methods:

    • Administered a ketamine (10 mg/kg, intravenous) bolus to both decerebrate and intact feline subjects.
    • Analyzed plasma samples to determine ketamine concentrations over time.
    • Modeled pharmacokinetic data using a two-compartment open model.

    Main Results:

    • A two-compartment open model effectively described ketamine pharmacokinetics in both groups.
    • Decerebrate cats exhibited significantly reduced apparent volume of distribution (peripheral and total) and post-distributive half-life (p < 0.05).
    • These findings indicate altered ketamine distribution and elimination in decerebrate animals.

    Conclusions:

    • Decerebration significantly impacts ketamine's pharmacokinetic profile in cats.
    • Plasma drug concentrations in decerebrate animals do not accurately reflect those in intact animals.
    • Emphasizes the necessity of correlating behavioral and neuronal data with drug concentrations, considering the animal's physiological preparation.

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