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Postmastectomy lymphangiosarcoma: experience with three patients and electron microscopic observations in one
Canadian Journal of Surgery. Journal Canadien De Chirurgie
|November 1, 1979
Summary
Radical mastectomy followed by irradiation can lead to lymphangiosarcoma. Preventing this rare cancer is vital, as current therapies are ineffective.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Lymphangiosarcoma is a rare malignancy.
- Post-mastectomy radiation therapy is a known risk factor.
Observation:
- Three patients developed lymphangiosarcoma after radical mastectomy and irradiation.
- The median latency period was 9.9 years.
Findings:
- No therapy, including chemotherapy, controlled the disease.
- All patients died with residual disease; two deaths were directly caused by lymphangiosarcoma.
Implications:
- Avoiding radical mastectomy with subsequent irradiation is crucial for preventing post-mastectomy lymphangiosarcoma.
- The tumor may originate from primitive vasoformative cells.